Our Virtual Existence: the Eternity is here!

What characterizes the existence of a person? The fact that it has a blood and flesh body, the actions and goals achieved during is life, or both? Like we all have a real existence, we propose to create a virtual existence for each one of us. Like our real life, our virtual life would have knowledge of our goals and desires in all areas. Like our real life, our virtual life would have autonomy. It would know all about us, our ID number and data, our IRSinformation, our health information, and so on. The "real I" should be able to define the preferences and goals of the "virtual I". Those preferences and goals should be possible to change along our life. It should be able to pursue those goals in our behalf. It should be able to learn, interact and adapt to the virtual environment, like our "real I" has to learn, interact and adapt tothe real environment. Our "virtual I" should exist, of course, in a virtual space: the Internet. It should seek our goals and preferences, inform and give advices to the "real I". It should be able to communicate all this to us through our home PC, our mobile phone, PDA, and so on. We should be able to carry our "virtual I", if we wish, with everything about us, in our mobiledevice or in a flash pen. Because it knows everything about us, itshould be able to represent us in the restaurant information system, in the IRS information system, in the health information system, in the Bank information system, and so on. Say goodbye to ID cards, driving licenses, passports, and so on. Our "virtual I" will represent us to the police and immigration officer. When our "real I" dies our "virtual I" can continue to live, representing and pursuing our goals. Our family and friends can continue to talk with us, through our "virtual I". - The eternity is here!What characterizes the existence of a person? The fact that it has a blood and flesh body, the actions and goals achieved during is life, or both? Like we all have a real existence, we propose to create a virtual existence for each one of us. Like our real life, our virtual life would have knowledge of our goals and desires in all areas. Like our real life, our virtual life would have autonomy. It would know all about us, our ID number and data, our IRSinformation, our health information, and so on. The "real I" should be able to define the preferences and goals of the "virtual I". Those preferences and goals should be possible to change along our life. It should be able to pursue those goals in our behalf. It should be able to learn, interact and adapt to the virtual environment, like our "real I" has to learn, interact and adapt tothe real environment. Our "virtual I" should exist, of course, in a virtual space: the Internet. It should seek our goals and preferences, inform and give advices to the "real I". It should be able to communicate all this to us through our home PC, our mobile phone, PDA, and so on. We should be able to carry our "virtual I", if we wish, with everything about us, in our mobiledevice or in a flash pen. Because it knows everything about us, itshould be able to represent us in the restaurant information system, in the IRS information system, in the health information system, in the Bank information system, and so on. Say goodbye to ID cards, driving licenses, passports, and so on. Our "virtual I" will represent us to the police and immigration officer. When our "real I" dies our "virtual I" can continue to live, representing and pursuing our goals. Our family and friends can continue to talk with us, through our "virtual I". - The eternity is here

Designing a multi-agent system for monitoring and operations recovery for an airline operations control centre

A operação de uma companhia área raramente acontece como planeado. São comuns os problemas relacionados com os aviões, com as tripulações e com os passageiros. As acções que têm como objectivo resolver estes problemas são conhecidas como Gestão das Irregularidades Operacionais. O Centro de Controlo Operacional da Companhia Aérea (CCO) tenta resolver estes problemas com o mínimo de impacto na operação, com o mínimo custo e, ao mesmo tempo, satisfazendo todas as regras de segurança requeridas. Normalmente, cada problema é tratado separadamente e algumas ferramentas têm sido propostas para ajudar no processo de tomada de decisão pelos coordenadores destes centros de controlo. Observamos o CCO da TAP Portugal, a maior companhia aérea Portuguesa, e, destas observações, várias hipóteses foram identificadas e algumas experimentadas. Acreditamos, e esta é uma das nossas principais hipóteses, que o paradigma do Sistema Multi-Agente (SMA) é mais adequado para representar a organização hierárquica de vários níveis e as várias funções (roles) existentes no CCO. Nesta tese, propomos o desenho e a implementação parcial de um SMA Distribuído que represente as várias funções existentes no CCO. Admitimos a hipótese de que, tirando partido do facto de que cada base operacional tem recursos específicos (quer aviões quer tripulantes) e juntando informações que digam respeito aos custos envolvidos (por exemplo, informação sobre vencimentos dos tripulantes, custos dos hotéis, entre outros), as soluções para os problemas detectados serão encontradas mais rapidamente e serão menos caras. Também admitimos a hipótese de que se utilizarmos agentes de software especializados que implementam diferentes soluções (heurísticas e outras soluções baseadas em modelos de investigação operacional e algoritmos de inteligência artificial) aplicadas ao mesmo problema, a robustez do sistema irá aumentar. Finalmente, acreditamos que a inclusão de um mecanismo de aprendizagem, que aprenda com a utilização anterior dos tripulantes, irá aumentar a qualidade das soluções. Estendendo esse mecanismo de forma a aprender o perfil de cada tripulante e aplicando esse conhecimento na geração de planeamentos (escalas) futuros, a gestão deste recurso tão caro será muito mais eficiente e o nível de satisfação de cada tripulante irá aumentar. Apresentamos um caso de estudo real, obtido no CCO da TAP, onde um problema relacionado com tripulantes é resolvido usando o SMA proposto. Apresentamos resultados computacionais, usando uma operação real da companhia aérea, incluindo a comparação com uma solução para o mesmo problema encontrada pelo operador humano do CCO. Mostramos que, mesmo para problemas simples e quando comparado com soluções encontradas por operadores humanos, no caso específico desta companhia aérea, é possível encontrar soluções válidas, em menos tempo e com menos custos.Nesta tese também mostramos como completamos a metodologia GAIA de forma a melhor analisar e desenhar o SMA proposto para o CCO. Para além de mostrarmos o rationale que está por trás da análise, desenho e implementação do nosso sistema, também mostramos como mapeamos as abstracções usadas no desenho orientado a agentes para código específico em JADE. As vantagens da utilização de uma análise de requisitos orientada a objectivos e a sua influência nas fases seguintes da análise e do desenho, também são apresentadas. Finalmente, propomos diagramas UML 2.0 para representação de vários deliverables da GAIA, tais como, estrutura organizacional, modelos de funções (role) e de interacções e modelos de agentes e de serviços.An airline schedule seldom operates as planned. Problems related with aircrafts, crew members and passengers are common and the actions towards the solution of these problems are usually known as operations recovery or disruption management. The Airline Operations Control Center (AOCC) tries to solve these problems with the minimum impact in the airline schedule, with the minimum cost and, at the same time, satisfying all the required safety rules. Usually, each problem is treated separately and some tools have been proposed to help in the decision making process of the airline coordinators. We have observed the AOCC of TAP Portugal, the major Portuguese airline, and, from those observations, several hypotheses have been identified and some of them experimented. We believe, and that is one of our main hypothesis, that the Multi-Agent System (MAS) paradigm is more adequate to represent the multi-level hierarchy organization and the several roles that are played in an AOCC. In this thesis we propose the design and partial implementation of a Distributed MAS representing the existing roles in an AOCC. We hypothesize that if we take advantage of the fact that each operational base has specific resources (both crew and aircrafts) and that if we include information regarding costs involved (for example, crew payroll information and hotels costs, among others), the solutions to the detected problems will be faster to find and less expensive. We also hypothesize that if we use specialized software agents that implement different solutions (heuristic and other solutions based in operations research models and artificial intelligence algorithms), to the same problem, the robustness of the system will increase. Finally, we believe that the inclusion of some kind of learning mechanism that learns from previous utilization of crew members will improve the solutions quality. Extending that learning mechanism to learn each crew member profile, and applying that knowledge for generating future schedules, the management of that expensive resource will be much more efficient and the level of satisfaction of each crew member will increase. We also present a real case study taken from TAP Portugal AOCC, where a crew recovery problem is solved using the MAS. Computational results using a real airline schedule are presented, including a comparison with a solution for the same problem found by the human operators in the Airline Operations Control Center. We show that, even for simple problems, and when comparing with solutions found by human operators in the case of this airline company, it is possible to find valid solutions, in less time and with a smaller cost. In this thesis we also show how we complement the GAIA methodology in order to better analyze and design the proposed MAS for the AOCC. Besides showing the rationale behind the analysis, design and implementation of our system, we also present how we mapped the abstractions used in agent-oriented design to specific constructs in JADE. The advantages of using a goal-oriented early requirements analysis and its influence on subsequent phases of analysis and design are also presented. Finally, we also propose UML 2.0 diagrams at several different levels for representation of GAIA deliverables, like organizational structure, role and interaction model, agent and service model

A multi-agent system for intelligent monitoring of airline operations

There are quite a few solutions for crew scheduling, including some commercial applications. The same happens for aircraft scheduling and for flight scheduling including revenue management. However, the airline operations problem did not receive the same attention has the other airline scheduling problems. In this paper we introduce this problem and report thework we are doing in the development of a Distributed Multi-agent System that will be capable of dealing with the crew and aircraft recovery problem, during the airline operations phase. The MAS deals with different operational bases and all bases cooperate to find the solutions to the local problems. Robustness is a key feature and we achieve that through redundancyin finding the possible solutions to the problem, using agents that compete in finding for the best solution to be applied. To be an Intelligent System some kind of learning must be available. We are using learning to define the crew members profile, to learn the use of stand by crew members and include this learning in future crew scheduling and in suggesting newsolutions based on previous decisions. Finally, we would like to explore the possibility of having a kind of electronic market for available crew members/aircrafts among airline companies, to be used in crew and aircraft recovery. This would work as a market of solutions to specificlocal problems and these solutions would compete with the recommended local solutions. To develop the system the latest MAS methodologies, frameworks, tools and technologies will be used. This includes GAIA, JADE, Agent-web services and IBM Rational suite of tools

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research